Survey on therapies with live ingredients

Most therapeutics for illnesses nowadays are passive substances (like small molecules or proteins) that interact with cells in our body. Do you know any medication or therapies that use genetically modified “active” or live ingredients (e.g. alive cells, intact viruses)?

Yes     No

Please provide your example(s) for the mentioned therapy(ies).

One example for a treatment with living ingredients would be CAR-T-Cell therapy for cancer treatment. It is therefore used for treating a lethal disease. Do you think using genetically modified living cells in this case (lethal) is the correct measure?

Yes     No

Stem cell-derived beta cell therapy for treating diabetes is another example. This is a treatment of a non-lethal disease. Do you think using genetically modified living cells in this case (non-lethal) is the correct measure?

Yes     No

What is the biggest concern you would have about a treatment with genetically modified cells or alive components in contrast to current established "passive" methods?

More unknown long-term side effects Harder to predict treatment impact More challenging to control or counteract in case of complications Greater danger of genetic changes in patients' (healthy) cells No additional concerns compared to conventional methods Other concern

Please specify your concern.

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