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Project Overview

Project Code: LS 01

Project name:

Analyzing the Chicken Interferon System by gene editing

TUM Department:

LS - Biosciences

TUM Chair / Institute:

Reproductive Biotechnology

Research area:

immunology, agriculture, biotechnology, infectious diseases

Student background:

BiologyBiotechnologyHealth SciencesMedicine

Further disciplines:

Planned project location:

TUM Campus Weihenstephan/Freising

Project Supervisor - Contact Details


Title:

Given name:

Benjamin

Family name:

Schusser

E-mail:

benjamin.schusser@tum.de

Phone:

08161712027

Additional Project Supervisor - Contact Details


Title:

Given name:

Mohanned

Family name:

Alhussien

E-mail:

mohanned.alhussien@tum.de

Phone:

Additional Project Supervisor - Contact Details


Title:

Given name:

Family name:

E-mail:

Phone:

Project Description


Project description:

Background:
Interferons (IFNs) are pivotal players in the innate immune response against viral infections. In contrast to mice models, the role of the chicken IFNs and their receptors are not fully understood due to the lack of investigative tools such as genetically modified chickens. To bridge this knowledge gap, we have successfully generated interferon receptor knockout (KO) chickens using CRISPR/Cas9 technology.

Objective:
We aim to elucidate the underlying mechanisms by which different classes of IFNs modulate the immune response in chickens. Additionally, we seek to identify the antiviral properties of IFNs, with the ultimate goal of contributing to the development of potential therapeutics for a broader spectrum of viruses, including those of veterinary and zoonotic significance.

Student tasks and benefits:
The student will contribute to this project by analyzing samples to characterize the underlying mechanism by which different class of IFN modulate immune response to different type of viral infections. The student will acquire basic knowledge in the field of avian immunology and virology, and will learn several techniques such as flow cytometer, qPCR, Histology, etc.

Expected Outcomes:
Through this research project, we anticipate gaining a comprehensive understanding of the avian IFN system and its modulation of immune responses to viral infections. By uncovering the mechanisms involved, we aim to contribute to the development of potential therapeutics with broader applications in both veterinary medicine and zoonotic disease management.

Working hours per week planned:

40

Prerequisites


Required study level minimum (at time of TUM PREP project start):

3 years of bachelor studies completed

Subject related:

Other:

  • Keine Stichwörter