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Project Overview

Project Code: MH 15

Project name:

Functional and mechanistic studies of novel regulators of B-cell responses

TUM Department:

MH - Medicine

TUM Chair / Institute:

Prof. Carsten Schmidt-Weber, ZAUM

Research area:

Immunology and Allergy

Student background:

BiochemistryBiologyBiotechnologyHealth SciencesMedicine

Further disciplines:

Participation also possible online only:

Planned project location:

Helmholtz Munich

Project Supervisor - Contact Details


Title:

Dr.

Given name:

Lesly

Family name:

Calderon

E-mail:

lesly.calderon@tum.de

Phone:

+49 89 318749116

Additional Project Supervisor - Contact Details


Title:

Given name:

Family name:

E-mail:

Phone:

Additional Project Supervisor - Contact Details


Title:

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E-mail:

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Project Description


Project description:

B-cell responses are essential for humoral immunity against pathogens because they lead to the generation of antibody-secreting cells that produce large amounts of antigen-specific antibodies. These cells also have the potential to become quiescent and long-lived, which is fundamental for immunological memory against pathogens. B-cell responses are also key mediators of diseases, such as allergies, antibody-mediated autoimmunity, and malignancies.
Our Group at the Institute of Allergy Research/ZAUM at Helmholtz Munich focuses on studying the processes of B lymphocyte activation and differentiation into effector B cells, such as antibody-secreting cells and memory B cells. We seek a highly motivated summer student to join our research team for an internship.
The lab previously established an in vivo model system for pooled single-guide RNA (sgRNA) CRISPR/Cas9 screening, identifying several novel regulators of B cell-mediated responses. The student’s project will explore the function and underlying molecular mechanisms of some newly identified regulators using novel experimental approaches and in vitro and in vivo mouse models.

Working hours per week planned:

39

Prerequisites


Required study level minimum (at time of TUM PREP project start):

3 years of bachelor studies completed

Subject related:

Other:

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